LARGE AREA HIGH RESOLUTION X-RAY DETECTOR FOR BIOMEDICAL RESEARCH

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
16623
Agency Tracking Number:
16623
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Radiation Monitoring Devices, (Currently Radiation Monitoring Devices, Inc)
44 Hunt Street, Watertown, MA, 02172
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Squillante, Michael R
Principal Investigator
(617) 926-1167
Business Contact:
1 R43 GM45639-01
() -
Research Institution:
n/a
Abstract
THE AVAILABILITY OF HIGH INTENSITY, SYNCHROTRON SOURCES TO PRODUCE HIGH FLUX, MONOCHROMATIC X-RAY BEAMS HAS RESULTED IN IMPORTANT ADVANCES IN MOLECULAR STRUCTURE DETERMINATION STUDIES INCLUDING THE DETERMINATION OF THE STRUCTURE OF LARGE, FRAGILE BIOLOGICAL MACROMOLECULES. ALTHOUGH THESE SOURCES REPRESENT A MAJOR ADVANCE IN TECHNOLOGY, AT PRESENT THERE ARE NO LARGE AREA DETECTORS WITH BOTH THE HIGH FLUX CAPABILITY AND GOOD SPATIAL RESOLUTION NECESSARY TO MAKE USE OF THE FULL POTENTIAL OF X-RAY DIFFRACTION MEASUREMENTS. TO ADDRESS THIS SITUATION, THE SPECIFIC AIM OF THE EFFORT IS TO DEVELOP THE TECHNOLOGY THAT WILL LEAD TO AN INNOVATIVE SOLID STATE, POSITION SENSITIVE X-RAY DETECTOR WHICH WILL HAVE THE PERFORMANCE NEEDED TO MORE FULLY UTILIZE THE POWER OF MODERN SYNCHROTRON SOURCES. WE WILL DEVELOP A LARGE AREA DETECTOR (POTENTIALLY METERS SQUARE) WITH 100MU M SPATIAL RESOLUTION, WIDE DYNAMIC RANGE AND HIGH X-RAY STOPPING POWER. THIS WILL BE A SIGNIFICANT BREAKTHROUGH IN THE STATE-OF-THE-ART AND WOULD BE A VALUABLE ASSET TO A VARIETY OF EXPERIMENTAL INVESTIGATIONS.

* information listed above is at the time of submission.

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