IMPLANTABLE PASSIVE DOSIMETER WITH REMOTE READOUT

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19134
Amount: $49,999.00
Phase: Phase I
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
44 Hunt St, Watertown, MA, 02172
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Gerald Entine
 (617) 926-1167
Business Contact
Phone: () -
Research Institution
N/A
Abstract
TO BE EFFECTIVE, A RADIATION THERPAY PORTOCOL SHOULD CONTROL THE CUMULATIVE DOSE DELIVERD TO A TUMOR TO BETTERN THAN 5%, WHILE MINIMIZING THE DOSE TO THE SURROUNDING TISSUE. PRESENTLY, THERE EXISTS NO PRACTICAL MEANS FOR ACUTALLY MEASURING IN VIVO, THE CUMULATIVE DOSE RECEIVED BY EITHER THE TUMOR OR THE SURROUNDING TISSUE. BOTH TLD'S, WHICH MUST BE REMOVED FROM THE BODY TO BE READ, AND MINIATURE ACTIVE RADIATION DETECTORS, WITH THEIR TRANSCUTANEOUS WIRES, HAVE FOUND VERY LIMITED APPLICATION BECAUSE OF THEIR READOUT PREOCEDURES. WE WILL DEVELOP AN IMPLANTABLE, PASSIVE DOSIMETER WHICH CAN BE READ REMOTELY WITHOUT TANSCUTANEOUS WIRES. WHEN FULLY DEVELOPED, THE DEVICES WILL BE ONLY SLIGHTLY LARGER THAN GRAINS OF RICE AND COULD BE IMPLANTED WITH A BIOPSY NEEDLE IN BOTH THE TUMOR AND THE SURROUNDING TISSUE PRIOR TO THE COURSE OF THERAPY. THE NEW DOSIMETERS ARE DESIGNED TO EXHIBIT A LINEAR CHANGE IN PROPERTIES WITH THE CUMULATIVE RADIATION DOSE. BY USING A REMOTE READOUT TECHNIQUE SIMILAR TO THOSE USED BY RETAIL STORES TO PREVENT SHOPLIFING, THE DEVICES COULD BE NONDESTRUCTIVELY READ AT WILL AND COULD PROVIDE THE DATA NEEDED FOR ACCURATE IRRADIATION OF TUMORS LOCATED IN CRITICAL AREAS.

* Information listed above is at the time of submission. *

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