Novel Wear Resistant and Thermally Insulative Materials

Award Information
Agency: Department of Defense
Branch: Army
Contract: DAAD13-00-C-5003
Agency Tracking Number: A992-1414
Amount: $730,000.00
Phase: Phase II
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
44 Hunt Street, Watertown, MA, 02472
DUNS: 073804411
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Arieh Karger
 Group Leader
 (617) 926-1167
 fries@mrcsb.com
Business Contact
 Gerald Entine
Title: Group Leader
Phone: () -
Email: fries@mrcsb.com
Research Institution
N/A
Abstract
The Phase I effort successfully integrated micro-APD arrays into a detection system that can accommodate many microscale analysis platforms, including genomic-based systems on glass, silicon, plastic and PDMS (poly-dimethylsiloxane). We demonstrated thefeasibility of our detection platform by developing a highly sensitive, low-cost prototype system, which consisted of an LED excitation source, an optical fiber, two plastic colored filters, the PDMS-based microfluidics, and the micro-APD detector array.This system achieved a sensitivity that measured concentrations of dilute fluorecein solutions down to 1 micro-M, and easily detected 3 micro-m diameter fluorescent latex spheres, which mimic tagged bacteria.We will research methods for identifying biological agents using a microfabricated sensing platform, and we will develop a low-cost, low-power, portable prototype that is capable of detecting and identifying bacteria in volumes of 100 micro-L, or less.With the addition of a sample collection and preparation module, the target sensitivity of the proposed system will provide a minimum detection sensitivity of 20 colony forming units (cfu)/liter of air for bacteria. The targeted identification responsetime is less than 5 minutes. The proposed microscale analysis system is based on the integration of a highly sensitive, photon-counting detection platform utilizing micro-APD arrays.

* Information listed above is at the time of submission. *

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