Microorganism Imprinted Polymers (MOIPs) for Detection of Biological Warfare Agents

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: M67854-03-F-7058
Agency Tracking Number: C031-0109
Amount: $69,996.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
44 Hunt Street, Watertown, MA, 02472
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Arieh Karger
 Group Leader, Sr. Scienti
 (617) 926-1167
Business Contact
 Gerald Entine
Title: President
Phone: (617) 926-1167
Email: GEntine@rmdinc.com
Research Institution
Radiation Monitoring Device, Inc. (RMD) will develop microorganism imprinted polymers (MOIPs) that purify, concentrate, and identify bacterial and viral wargare agents. In Phase I we will develop polymer formulations and fluorescent labeling strategiesfor MOIPs targeted towards E. coli and B. globigii vegetative cells. We will aslo demonstrate the feasibility of detecting biowarfare agents. In Phase II we will imprint viruses and bacterial spores. The MOIP sensors will be characterized with respect totheir sensitivity, response time, selectivity, stability, and reversibility. To conclude this program, a portable prototype will be designed, fabicated, and tested. The prototype will use an array of MOIPs, housed in a microfluidic format, that will bematched with a PIN photodiode array detector. We will interface the photodiode with an artificial neural network for signal processing. It is anticipated that microorganism imprinted polymers (MOIPs) will be capable of bacterial detection,identification, purification, and concentration. MOIP sensors will be used in portable instruments by combat troops and emergency responders to detect and identify bacterial warfare agents in aerosol samples. For purifying samples, these sensors will beapplicable as the front-end component for instruments, such as a PCR-based detectors. The capability of concentrating microorganisms will increase the sensitivity of biological detectors. Furthermore, MOIPs will identify waterborne pathogens and pollenallergens for water and indoor air quality monitors.

* Information listed above is at the time of submission. *

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