A SIMPLE, HIGH-SPEED, HIGHLY SENSITIVE VIRAL SENSOR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI052547-01
Agency Tracking Number: AI052547
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
RADIATION MONITORING DEVICES INC, 44 HUNT ST, WATERTOWN, MA, 02472
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ARIEH KARGER
 (617) 926-1167
 AKARGER@RMDINC.COM
Business Contact
 GERALD ENTINE
Phone: (617) 926-1167
Email: GENTINE@RMDINC.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant):Radiation Monitoring Devices, Inc. proposes to design a simple, high speed, highly sensitive viral detection instrument. This instrument will measure fluorogenic reporter genes, which hybridize to complementary viral gene target inside a capillary waveguide. Our single-photon sensitive Geiger-mode, microavalanche photodiodes (micro-APDs) will enable low limits of detection of viruses. The micro-APD :an be battery-powered because of its low voltage requirement and rugged characteristics. We will also use active quenching circuitry, which allows measurement of a large dynamic range (-10 E 6), needed for continuous monitoring through exponential nucleic acid amplification. In Phase I, we will design the waveguide sensor, the micro-APD detection system, and establish fluorogenic probe chemistry. In Phase I, we will design a system for viral load detection, array formatting, establish nucleic acid amplification reactions, test a virus, and explore the instrument's versatility.

* Information listed above is at the time of submission. *

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