Novel Scintillator for PET Imaging

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-FG02-04ER84057
Agency Tracking Number: 75530S04-I
Amount: $750,000.00
Phase: Phase II
Program: SBIR
Awards Year: 2005
Solicitation Year: 2004
Solicitation Topic Code: 23 c
Solicitation Number: DOE/SC-0072
Small Business Information
44 Hunt Street, Watertown, MA, 02472
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Michael Squillante
 (617) 668-6808
Business Contact
 Gerald Entine
Title: Dr.
Phone: (617) 668-6800
Research Institution
75530S Positron emission tomography (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as cancer, Alzheimer's disease, head trauma and stroke. However, the performance of current clinical PET systems is limited by available detector technology, and there is an urgent need for improvement in PET instrumentation, in order to exploit the full potential of this promising technique. This project will develop a new detector material for PET that shows high light output, fast response and high sensitivity, leading to a detector with high energy and timing resolution. Other benefits include significantly reduced scatter and randoms, the main limitations in three-dimensional PET, and the possibility of time-of-flight PET imaging. During Phase I, crystals of the new scintillation material were grown and their scintillation properties were measured. These crystals showed exceptionally high light output, fast response, and excellent energy and timing resolution. During Phase II , larger crystals of the proposed scintillation material will be grown. The light output, decay time, and energy and timing resolution of these large crystals will be determined as a function of the doping level. Arrays will be built using the new scintillation crystals and PET modules will be assembled and tested using these arrays. Commercial Applications and Other Benefits as described by the awardee: The detector technology should be very promising for PET and other medical imaging modalities such as X-ray computed tomography. It also should be useful in nuclear and particle physics research, astronomy, nuclear waste characterization, homeland security, and geophysical exploration.

* Information listed above is at the time of submission. *

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