A Fast, High Luminosity Scintillator for PET

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 4R44EB004290-02
Agency Tracking Number: EB004290
Amount: $356,136.00
Phase: Phase II
Program: SBIR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: N/A
Solicitation Number: PHS2005-2
Small Business Information
RADIATION MONITORING DEVICES, INC.
Radiation Monitoring Devices Inc, 44 Hunt St, Watertown, MA, 02472
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 GERALD ENTINE
 (617) 926-1167
 GENTINE@RMDINC.COM
Business Contact
 GERALD ENTINE
Phone: (617) 926-1167
Email: GENTINE@RMDINC.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a nuclear imaging modality that makes use of a range of positron-emitting tracers to provide images that reflect different parameters relevant to tumor biology. Tumor cells generally differ from normal cells in many respects, including rates of glucose utilization, proliferation and protein synthesis. PET tracers such as glucose and thymidine analogs, and amino acids, generally show high uptake in tumor cells. Indeed, whole-body PET imaging with 18Ffluorodeoxyglucose (FDG) is now a well established diagnostic procedure that is used for staging and assisting in management choices of patients with many different types of cancers. Recent developments in PET technology are leading towards more specialized PET systems, particularly for breast imaging and applications in breast cancer. The motivation is to obtain better performance at a lower cost than with conventional whole-body PET scanners. It is clear that PET technology is playing a prominent and an increasingly visible role in modem cancer research and clinical diagnosis. However, there is urgent need for improvement in PET instrumentation in order to exploit the full potential of this powerful imaging modality. The goal of the proposed effort is to investigate crystals of a new promising scintillator for PET imaging.

* information listed above is at the time of submission.

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