Digital 2-D Neutron Detector for Protein Function Sudies

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
1R43RR021257-01
Award Id:
75602
Agency Tracking Number:
RR021257
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Radiation Monitoring Devices Inc, 44 Hunt St, Watertown, MA, 02472
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
IRINASHESTAKOVA
(617) 668-6929
Business Contact:
GERALDENTINE
(617) 926-1167
GENTINE@RMDINC.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Information on the structure and function of proteins is important for unveiling the biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, however is not well suited for analyzing hydrogen atoms and water molecules. It has been shown that the thermal neutrons are a far better tool for probing interactions between proteins and water, because they interact directly with light nuclei, not their electron clouds as in case of x-ray diffraction. However, the use of thermal neutrons has been underutilized in this country, partially due to the lack of adequate detectors. Current two-dimensional detector for neutrons do not provide adequate area coverage, spatial resolution, sensitivity, and geometry best suited for the given application. To address these issues, we propose to develop a large area digital imaging detector for thermal neutrons, which offers a better combination of surface coverage, spatial resolution, detection efficiency and dynamic range than is currently possible. The detector is based on an novel, large-area scintillator, tailored for imaging thermal neutrons, coupled tot a digital readout. This thermal neutron imaging system will advance the state-of-the-art of detectors used in macromolecular crystallography and neutron radiography.

* information listed above is at the time of submission.

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