High Sensitivity, 2-D Solid State Sensor Array/Rapid MCG

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HL081910-01
Agency Tracking Number: HL081910
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: N/A
Solicitation Number: PHS2005-2
Small Business Information
Radiation Monitoring Devices Inc, 44 Hunt St, Watertown, MA, 02472
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (617) 926-1167
Business Contact
Phone: (617) 926-1167
Research Institution
DESCRIPTION (provided by applicant): Magnetocardiography (MCG) has been shown to offer powerful disease detection and diagnostic capabilities in both humans and animals not readily achieved with standard ECG and echocardiography, including the ability to map ischemic regions in the heart, and monitor arrhythmia. Fetal magnetocardiography (fMCG) has been successfully employed for the non-invasive study of arrhythmia and other conditions of the fetus in utero. However, due to the exceedingly small magnetic fields associated with the heart, current MCG systems use super conducting quantum interference devices (SQUID) as sensors. Complexities in fabricating and using SQUIDs, including coils, shielding, cooling and electronics, make them exceedingly expensive. These limitations have prevented MCG from achieving widespread clinical use. RMD proposes a new, solid-state, high density, 2-D sensor array that will revolutionize MCG technology so that it can be used in both the clinical setting with human subjects, and for research with animals to develop new treatments and pharmaceuticals. The proposed technology will make possible large area, high density, 2-D sensor arrays for excellent image resolution (~250 microns), high speed imaging without scanning, and sensitivity of ~10-13T/VHz. The sensors will also result in substantial reductions in both the complexity and cost of MCG instrumentation. The goal of the Phase I program is to show that the proposed technology can be used to perform MCG, and that the data can be mapped to produce images of the heart. RMD has assembled a strong research team consisting of a cardiologist, biophysicist, scientists and engineers to conduct the Phase I program. The team has substantial experience in measuring minute magnetic fields, and analyzing ECG in both animals and human subjects.

* Information listed above is at the time of submission. *

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