Single Molecule Instrument for Surface Enhanced Raman Optical Activity of Biomolecules

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNA06CA67C
Agency Tracking Number: 053920
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solitcitation Year: 2005
Solitcitation Topic Code: S2.05
Solitcitation Number: N/A
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt St, Watertown, MA, 02472-4699
Duns: 073804411
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Rajan Gurjar
 Principal Investigator
 (617) 926-1167
 RGurjar@RMDInc.com
Business Contact
 Gerald Entine
Title: President
Phone: (617) 926-1167
Email: GEntine@RMDInc.com
Research Institution
N/A
Abstract
Stereochemistry is an essential element of our organic life. Only certain enantiomers are useful as drugs for the human body. Raman Optical Activity (ROA) and vibrational circular dichroism (VCD) provide stereochemical information down to bond levels. Many biomolecules like proteins and DNA can be studied for understanding their structural chemistry and structure related dynamics. These methods do not require material in the crystalline form and hence can be very useful tools. However, ROA signals are even weaker than the Raman signals. Phase I and Phase II work will focus on enhancing Raman optical Activity (ROA) signals in amino acids and biomolecules, which includes measurement of vibrational circular dichroism by using surface enhanced process involving nanoclusters. The use of nanoparticles is known to enhance Raman signals by several orders of magnitude. Our goal is to achieve similar gains in ROA signals. To achieve it, we will use a sensitive detection system in combination with improved surface enhanced chemistry and microfluidics-based single-molecule detection techniques. This will result in improved precision of measurement and shorten measurement time, which currently takes several hours to days.

* information listed above is at the time of submission.

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