Parallel Detection of Multiple Biomarkers During Spaceflight

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNA06AA13C
Agency Tracking Number: 053891
Amount: $69,999.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2005
Solicitation Topic Code: X11.02
Solicitation Number: N/A
Small Business Information
44 Hunt St, Watertown, MA, 02472-4699
DUNS: 073804411
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Daniel Hall
 Principal Investigator
 (617) 926-1167
Business Contact
 Gerald Entine
Title: President
Phone: (617) 926-1167
Research Institution
Maintaining the health of astronauts during extended spaceflight is critical to the success of the mission. Radiation Monitoring Devices, Inc. (RMD) proposes an instrument to monitor astronauts' physiological responses to stress, microgravity, radiation, infection, and pharmaceutical agents through detection of multiple biological markers. This will be accomplished under conditions of microgravity, within the weight, size and power requirements of space missions, and with minimal human intervention. One representative biomarker of interest is 8-oxo-dG that serves as an indicator of oxidative DNA damage from radiation, chemicals, inflammation, and by-products of metabolism. Upon repair of the damaged DNA, 8-oxo-dG is excreted into the urine where it may be conveniently monitored. However, serious obstacles to detection and quantification arise due to the low amounts present and the complex chemical composition of urine. Current techniques suffer from at least one of the following shortcomings: they are slow and labor-intensive, require complex instrumentation and a highly-trained operator, cannot be easily multiplexed to monitor many analytes, consume large amounts of reagents, and are not compatible for use under microgravity. We will overcome these limitations by incorporating all analytical steps into a single microfluidic chip. Our system will utilize affinity purification and electrochemical detection.

* Information listed above is at the time of submission. *

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