Microfluidic Cytometer for Complete Blood Count Analysis

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$599,965.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
NNJ07JA11C
Award Id:
77696
Agency Tracking Number:
053889
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
44 Hunt Street, Watertown, MA, 02472
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
073804411
Principal Investigator:
LouisStrong
Principal Investigator
(617) 668-6801
lstrong@rmdinc.com
Business Contact:
NancyMarshall
Business Official
(617) 668-6801
NMarshall@RMDInc.com
Research Institute:
n/a
Abstract
We will fabricate and test microfluidic designs for a micro-electromechanical system based complete blood count (CBC) analysis in separate modules and integrate them into a working prototype. A first module constitutes a hydrodynamic focusing injector and cell impedance meter. A second module takes hydrodynamically focused cells and measures light scatter in the forward and orthogonal directions, as well as of fluorescence emission intensities from specific cell types using novel signal collection designs and micrometer scale, and Geiger-mode avalanche photodiodes that produce time-correlated photocount statistics from multiple optical sources. The third module will serve for blood sample dilution, routing, automated lysing and removal of human erythrocytes. This unit will also incorporate a sensor for measuring hemoglobin (Hgb) concentration. The proposed blood analyzer will utilize innovative optical and fluidic designs on a modular platform that enable compactness, high sensitivity, and robust service, while requiring no operator intervention.

* information listed above is at the time of submission.

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