Microfluidic Cytometer for Complete Blood Count Analysis

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNJ07JA11C
Agency Tracking Number: 053889
Amount: $599,965.00
Phase: Phase II
Program: SBIR
Awards Year: 2007
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
44 Hunt Street, Watertown, MA, 02472
DUNS: 073804411
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Louis Strong
 Principal Investigator
 (617) 668-6801
 lstrong@rmdinc.com
Business Contact
 Nancy Marshall
Title: Business Official
Phone: (617) 668-6801
Email: NMarshall@RMDInc.com
Research Institution
N/A
Abstract
We will fabricate and test microfluidic designs for a micro-electromechanical system based complete blood count (CBC) analysis in separate modules and integrate them into a working prototype. A first module constitutes a hydrodynamic focusing injector and cell impedance meter. A second module takes hydrodynamically focused cells and measures light scatter in the forward and orthogonal directions, as well as of fluorescence emission intensities from specific cell types using novel signal collection designs and micrometer scale, and Geiger-mode avalanche photodiodes that produce time-correlated photocount statistics from multiple optical sources. The third module will serve for blood sample dilution, routing, automated lysing and removal of human erythrocytes. This unit will also incorporate a sensor for measuring hemoglobin (Hgb) concentration. The proposed blood analyzer will utilize innovative optical and fluidic designs on a modular platform that enable compactness, high sensitivity, and robust service, while requiring no operator intervention.

* Information listed above is at the time of submission. *

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