Digital 2-D Neutron Detector for Protein Function Studies

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$830,250.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
2R44RR021257-02A1
Agency Tracking Number:
RR021257
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
RADIATION MONITORING DEVICES, INC.
44 Hunt Street, Watertown, MA, 02472
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
073804411
Principal Investigator:
IRINA SHESTAKOVA
(617) 668-6929
Business Contact:
GERALD ENTINE
() -
gentine@rmdinc.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Information on the structure and function of proteins is important for unveiling biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, howeve r, it is not well suited for analyzing hydrogen atoms and water molecules. It has been shown that the thermal neutrons are a far better tool for probing interactions between proteins and water, because they interact directly with light nuclei, not their el ectron clouds as in case of x-ray diffraction. However, the use of thermal neutrons has been underutilized, partially due to the lack of adequate detectors. Current two-dimensional detectors for neutrons do not provide adequate area coverage, spatial resol ution, sensitivity, and geometry best suited for the given application. To address these issues, we propose to develop a large area digital imaging detector for thermal neutrons, which offers a better combination of surface coverage, spatial resolution, de tection efficiency and dynamic range than is currently possible. The detector is based on a novel, large-area scintillator, tailored for imaging thermal neutrons, coupled to a digital readout. This thermal neutron imaging system will advance the state-of-t he-art of detectors used in macromolecular crystallography and neutron radiography. High resolution neutron imaging will provide better insights into biological systems, and polymers and other ordered structures. For example, it will provide better underst anding of disease progression, improved insights into viral structures through neutron diffraction studies. The proposed detector could be employed at any neutron source facility and would help to advance basic research in protein mechanisms as well as dru g design. Non-biomedical applications could be found in non-destructive testing and secuity scanning at entry ports and strategic facilities. The goal of this Phase II project is to develop at high spatial resolution scintillator for neutron macromolec ular crystallography, which compliments x-ray crystallography in its ability to precisely locate hydrogen atoms in protein molecules. The information on hydrogen location is important for monitoring protein dynamics and helps to understand nature of diseas e. The proposed detector could be employed at any neutron source facility and would help to advance research of protein mechanisms as well as drug design.

* information listed above is at the time of submission.

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