TREATMENT OF MIGRAINE ATTACKS BY DRUG AEROSOL INHALATION

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$270,089.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43NS044800-01
Award Id:
61194
Agency Tracking Number:
NS044800
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ALEXZA MOLECULAR DELIVERY CORPORATION, 1001 E MEADOW CIR, PALO ALTO, CA, 94303
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JOSHUARABINOWITZ
(650) 687-3903
JRABINOWITZ@ALEXZA.COM
Business Contact:
JOSHUARABINOWITZ
(650) 687-3909
JRABINOWITZ@ALEXZA.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Migraine is a serious condition affecting millions of Americans. Patients with migraine strongly desire more rapid headache relief than current medications provide. A promising approach to expediting pain relief is delivery of existing drugs to the systemic circulation more rapidly via aerosol inhalation. The major technical hurdle in this rapid delivery approach is generation of is aerosols of sufficiently small particle size. This obstacle is overcome by ALEXZA's novel aerosol generation approach, which can produce very small particle aerosols without using any excipients or entrainers. Our technique has already proven to be successful on several FDA drugs. Production of the aerosol occurs nearly instantaneously, making it ideal for inhalation drug delivery. The mass median aerodynamic diameter of the aerosol is typically about one micron, an ideal size for transmission through the tracheobronchial airways and deposition onto the alveoli. In this phase of the grant, we will demonstrate the ability to aerosolize one or more drugs for migraine without degradation or impurities and confirm the small particle size and in vitro biological activity of the evolved aerosol. Completion of the aims of Phase I will launch us into Phase II studies and towards the commercialization of an improved migraine treatment.

* information listed above is at the time of submission.

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