SBIR Phase I: Large-Scale Production of Stearidonic Acid from Microalgae for Human Health

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0610770
Agency Tracking Number: 0610770
Amount: $99,888.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2005
Solicitation Topic Code: BT
Solicitation Number: NSF 05-605
Small Business Information
3488 Bramlet, Clemmons, SC, 27012
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Fan Lu
 (336) 577-4354
Business Contact
 Fan Lu
Title: Dr
Phone: (336) 577-4354
Research Institution
This Small Business Innovative Research (SBIR) Phase I project demonstrates the feasibility of producing stearidonic acid from microalgae for human consumption to combat cardiovascular diseases (CVD). The cardiovascular benefits of fish oil enriched in omega-3 polyunsaturated fatty acids (n-3 PUFAs) are well-documented. Despite overwhelming evidence and strong recommendations supporting the health benefits of n-3 PUFAs, the consumption of n-3 PUFAs remains low in the American population, due mainly to unpleasant odor and taste of fish oil and persistent questions about environmental contaminations. A natural alternative to fish oil that could supplement the intake of n-3 PUFA would be predicted to reduce the overall incidence in CVD. Stearidonic acid (SDA) has been identified recently as the most promising alternative to fish oil for preventing cardiovascular diseases. However, the natural source of SDA is limited only in a few plants. The feasibility of growing mass quantities of these plants is questionable and the toxicology profile of these plants remains to be a concern. This research solves this problem by exploiting SDA-rich microalgae as an alternative source of natural SDA for human consumption. This research will be able to produce SDA-rich microalgae as nutraceutical products for Americans to improve health. Commercially, this project aims at production of dietary stearidonic acid from microalgae. This project will establish a commercially viable microalgal biotechnology for production of SDA, targeted at competition with the multi-billion dollar fish oil market.

* information listed above is at the time of submission.

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