A Pb-212 Generator Using Resistant Substrate and Rn Cold Trapping

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41CA135857-01A1
Agency Tracking Number: CA135857
Amount: $111,339.00
Phase: Phase I
Program: STTR
Awards Year: 2009
Solicitation Year: 2009
Solicitation Topic Code: N/A
Solicitation Number: PHS2009-2
Small Business Information
ALPHAMED, INC, 150 Ellery Street, Wrentham, MA, 02093
DUNS: 096639922
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 GARY EHRHARDT
 () -
 EHRHARDTG@MISSOURI.EDU
Business Contact
 RICHARD TESTA
Phone: (774) 571-9415
Email: fe2plus@comcast.net
Research Institution
 UNIVERSITY OF MISSOURI
 UNIVERSITY OF MISSOURI
UNIVERSITY HALL
COLUMBIA, MO, 65211 4919
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Targeted Pb-212 therapy in preclinical animal tests has shown a cure in groups receiving the highest dose of this therapy. Scaling the dose that was most efficacious in animal studies to people would bring the human dose required from 50 to 100 mCi. This application will research an approach that would provide a generator system that would support these requirements. The proposed work will investigate a generator system that would trap the short-lived radon-220 and isolate and test Pb-212/Bi-212 obtained. The Ra-224 and Th-228 emanation generators would be scaled up to the multi-millicurie level and assessment of their performance over time, including overall yield and verification of zero breakthrough of Ra-224 or Th-228. Finally, the suitability of the product Pb-212/Bi-212 to label anti- melanoma peptide moieties and the improved specific activity of Pb-212 expected of an emanation generator will be tested. PUBLIC HEALTH RELEVANCE: A cure for melanoma, a deadly form of skin cancer, has been demonstrated in preclinical animal tests using Pb-212 labeled peptide. As this therapy moves to the clinic the current generator system needs to be improved to accommodate higher dose levels that are anticipated to be administered.

* Information listed above is at the time of submission. *

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