A Pb-212 Generator Using Resistant Substrate and Rn Cold Trapping

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$111,339.00
Award Year:
2009
Program:
STTR
Phase:
Phase I
Contract:
1R41CA135857-01A1
Award Id:
93506
Agency Tracking Number:
CA135857
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ALPHAMED, INC, 150 Ellery Street, Wrentham, MA, 02093
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
096639922
Principal Investigator:
GARYEHRHARDT
() -
EHRHARDTG@MISSOURI.EDU
Business Contact:
RICHARDTESTA
() -
fe2plus@comcast.net
Research Institute:
UNIVERSITY OF MISSOURI

UNIVERSITY OF MISSOURI
UNIVERSITY HALL
COLUMBIA, MO, 65211 4919

Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Targeted Pb-212 therapy in preclinical animal tests has shown a cure in groups receiving the highest dose of this therapy. Scaling the dose that was most efficacious in animal studies to people would bring the human dos e required from 50 to 100 mCi. This application will research an approach that would provide a generator system that would support these requirements. The proposed work will investigate a generator system that would trap the short-lived radon-220 and isola te and test Pb-212/Bi-212 obtained. The Ra-224 and Th-228 emanation generators would be scaled up to the multi-millicurie level and assessment of their performance over time, including overall yield and verification of zero breakthrough of Ra-224 or Th-228 . Finally, the suitability of the product Pb-212/Bi-212 to label anti- melanoma peptide moieties and the improved specific activity of Pb-212 expected of an emanation generator will be tested. PUBLIC HEALTH RELEVANCE: A cure for melanoma, a deadly form of skin cancer, has been demonstrated in preclinical animal tests using Pb-212 labeled peptide. As this therapy moves to the clinic the current generator system needs to be improved to accommodate higher dose levels that are anticipated to be administ ered.

* information listed above is at the time of submission.

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