Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$69,990.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
HDTRA1-10-P-0040
Agency Tracking Number:
C101-102-0011
Solicitation Year:
n/a
Solicitation Topic Code:
CBD 10-102
Solicitation Number:
n/a
Small Business Information
Physical Optics Corporation
Photonic Systems Division, 20600 Gramercy Place, Bldg. 100, Torrance, CA, 90501
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
153865951
Principal Investigator:
Gregory Zeltser
Principal Scientist
(310) 320-3088
psproposals@poc.com
Business Contact:
Gordon Drew
Chief Financial Officer
(310) 320-3088
gedrew@poc.com
Research Institution:
n/a
Abstract
To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to develop a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses in-house developed mature components. POC's innovations in the nanocarrier (NC) construct and in the design of the inhaler, which is capable of delivering a single dose from the MATEN during one deep and slow inspiration, will enhance the bioavailability for antisense therapeutics that is necessary for the prophylaxes and early treatment of warfighters against emerging bio-warfare threats. As a result, this technology offers a formulation that is stable at ambient temperature, minimizes the potential for introduction of immunogenic materials and the bulk and complexity of dispensing, and which directly addresses the requirements of the Transformational Medical Technologies Initiative (TMTI) program. In Phase I, POC will demonstrate the feasibility of the MATEN by demonstrating product stability and establishing enhanced bioavailability in an animal model. In Phase II, POC will optimize candidate formulation for maximum bioavailability and conduct initial pharmacokinetic and pharmacodynamic studies in an animal model.

* information listed above is at the time of submission.

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