NOVEL DRUG DISCOVERY FOR MULTIPLE SCLEROSIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2003
Program:
SBIR
Phase:
Phase I
Contract:
1R43NS047767-01
Award Id:
66688
Agency Tracking Number:
NS047767
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ALTOR BIOSCIENCE CORPORATION, 2810 N COMMERCE PKY, MIRAMAR, FL, 33025
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
PETER RHODE
(954) 443-8600
PETERRHODE@ALTORBIOSCIENCE.COM
Business Contact:
(954) 443-8600
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The long-term objective of this project is to develop small molecule inhibitors of TCR:MHC class II-peptide interactions for the treatment of multiple sclerosis (MS). The strong genetic association between specific MHC class ll alleles, such as HLA-DR2 (DRB1*1501), and susceptibility to MS provides support to a mechanism in which disease-associated MHC molecules selectively present myelin antigens that activate CD4 T cells. The hypothesis of this project is that small molecules that block TCR:HLA-DR2/peptide complex formation can prevent autoreactive T cell activation and chronic inflammatory processes in MS lesions. The investigator has developed sensitive screening assays to detect TCR:HLA-DR2/peptide interactions and methods to produce sufficient amounts of soluble and functional TCR and HLA-DR2/peptide reagents to support analysis of librarys of small molecules. Preliminary studies with another TCR:pMHC pair demonstrate that compounds that inhibit TCR:pMHC interaction can be identified using these screening methods. The specific aims of the project are to further develop high-throughput screening assays to identify and characterize small molecules that inhibit TCR:HLA-DR2/peptide interactions, to examine a large and diverse collection of small molecules for inhibitory activity and to test the immunosuppressive effects of these compounds in T cell-based assays. The results from these studies will provide useful information about TCR:pMHC interactions and could form the basis of a novel class of immunosuppressive drugs to treat human T-cell mediated autoimmune diseases.

* information listed above is at the time of submission.

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