Self-Organizing Biomolecular Materials as Structural and Patterning Elements for Device Fabrication

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 28743
Amount: $599,093.00
Phase: Phase II
Program: SBIR
Awards Year: 1996
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
97 Dorcar Rd, Newton, MA, 02159
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr. Parshuram Rath
 (617) 244-9324
Business Contact
Phone: () -
Research Institution
The engineering of materials on a nanometer scale is an important technological goal which would facilitate the development of a new generation of materials and devices. A variety of biological membranes exhibit self-assembly into 2-D arrays including the purple membrane from Halobacteria salinarium and the S-layer from Sulfolobus acidocaldarius. Methods have been developed to use these membranes as patterning elements and templates for device fabrication. In addition, conditions have been found where self-assembled membranes are stable up to 140 degrees Celsius. In Phase I AmberGen, Inc. will evaluate several new methods for characterizing and controlling self-assembly in these systems. These methods include: i) genetic engineering and in vitro production of self-assembling proteins with novel features for device fabrication; ii) site-specific incorporation of special linker molecules into proteins for the regulation of self-assembly, attachment to device substrates, co-crystallization of other biologically active proteins and patterning within a self-assembled array; iii) attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy for investigating the link between biomolecular structure and macroscopic self-assembly.

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