Microarray Assay for Detection of Lab Animal Pathogens

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$121,713.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI060215-01
Award Id:
71242
Agency Tracking Number:
AI060215
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AMBERGEN, INC., 1106 COMMONWEALTH AVE, BOSTON, MA, 02215
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JERZY OLEJNIK
(617) 975-0685
JERZY@AMBERGEN.COM
Business Contact:
NORMAN PRIEBATSCH
(617) 975-0688
NEP@AMBERGEN.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The main goal of this project is to develop a microarray based system for comprehensive health assessment of laboratory animals. This microarray based test would be capable of simultaneous testing for the presence of all relevant pathogens and would require only a small amount of blood or serum. During Phase I, AmberGen in collaboration with Pulsar Clinical Technologies Inc., a subcontractor on this project, plans to develop and evaluate critical components of a microarray assay system for the detection of multiple pathogen-specific antibodies circulating in blood of laboratory animals. This integrated system will be based on a proprietary microarray technology fabrication method utilizing nitrocellulose suspension. This method results in microarray substrates with high binding capacity and low background fluorescence. During Phase I several critical components of this assay system will be evaluated, including antigen binding capacity, sensitivity, specificity and reproducibility using several model antigens derived from mouse pathogens and mouse sera of known status. During Phase II a microarray assay capable of testing for all relevant pathogens in mice will be developed for animal facilities use. Dr. Nirah Shomer, Associate Director of Boston University Animal Science center will serve as a consultant on this project.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government