Detection of active biological toxins by exploiting native binding specificities

Detection of active biological toxins by exploiting native binding specificities

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: FA4819-15-C-0016
Agency Tracking Number: C2-0416
Amount: $990,642.00
Phase: Phase II
Program: SBIR
Awards Year: 2014
Solicitation Year: 2014
Solicitation Topic Code: CBD14-101
Solicitation Number: 2014.1
Small Business Information
196 Sterling Dr, Bountiful, UT, 84010
DUNS: 078282228
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Vojtech Svoboda Vojtech Svoboda
 CEO
 (256) 714-8951
 vojtech@binergyscientific.com
Business Contact
 Mrs. Martina Svoboda
Title: SSTM
Phone: (256) 714-8936
Email: martina@binergyscientific.com
Research Institution
N/A
Abstract
A chemical threat agent mode of action is often initiated through a selective interaction with a biological molecule or structure. The agent binding mimics normal cellular processes, but then overruns natural control mechanisms leading to toxic and lethal effects. The binding is used as a basis for sensing the agent. We are exploiting the native binding mechanism, designing and producing prototypes of sensing elements that provide benefits over conventional antibody - based systems. First, the direct detection in portable field applicable prototype eliminates bulky and unstable antibodies. Our custom developed interfaces allow for higher loading of the recognition molecules on the transducer, increasing its sensitivity and dynamic range. Additionally, extended stability of our tranducer provides sufficient storage and operation lifetimes for field application. Another advantage gained by using the native interaction mechanism for detection combined with the transducer design reduces false - positives and increases reliability. Only the active agent binds its native target molecule unlike antibody based detection where similar cross - reacting biomolecules or denatured agent actuate a signal. The concept limits interferences and efforts that may attempt to mask or mimic chemical threats. The Phase II project focuses on transition of the proven concept into portable integrated fully functional prototype of the detector.

* Information listed above is at the time of submission. *

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