Burkholderia antibody molecules for therapeutics and diagnostics

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-15-C-0072
Agency Tracking Number: C2-0414
Amount: $999,999.81
Phase: Phase II
Program: SBIR
Solicitation Topic Code: CBD14-105
Solicitation Number: 2014.1
Timeline
Solicitation Year: 2015
Award Year: 2015
Award Start Date (Proposal Award Date): 2015-09-25
Award End Date (Contract End Date): 2017-09-24
Small Business Information
7050 Burleson Rd., Austin, TX, 78744
DUNS: 611930244
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr. Sanesh Subramanya
 DIRECTOR OF ANIMAL HEALTH
 (512) 707-8993
 sandeshs@biooscientific.com
Business Contact
 Lance Ford
Title: Dr.
Phone: (512) 707-8993
Email: lford@biooscientific.com
Research Institution
N/A
Abstract
Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram - negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. This Phase II SBIR project will build on the success of our Phase I work, which established methods for generating monoclonal antibodies (MAbs) that bind surface carbohydrates and proteins of these Tier 1 Burkholderia pathogens. In Phase II, MAbs generated with these methods will be screened with a combination of computational, immunological, biophysical, and protection assays. The outcome of Phase II will be a selected subset of MAbs that, based on these assays, have the best functional properties for development as therapeutics. In subsequent phases of this work, the immunological properties and manufacturing capabilities of the MAb subset will be further optimized. The ultimate purpose of these studies is to develop these MAbs for clinical use to neutralize Burkholderia infections in humans.

* Information listed above is at the time of submission. *

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