Diode Laser-based Biosensor for Detection of Biological Warfare Agents

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$100,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
28320
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
American Research Corp Of Va
P.o. Box 3406, Radford, VA, 24143
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr. Russell J. Churchill
(703) 731-0655
Business Contact:
() -
Research Institution:
n/a
Abstract
The need for simple and practical instrumentation for rapid identification and detection of biological agents has been recognized as an important research area in sensor development. Specific antibody/antigen binding, in conjunction with evanescent wave excited fluorescence sensing, has been applied to the detection of toxins and chemical and biological warfare materials. However, there remains a need to develop a reliable, highly sensitive and lightweight instrument capable of performing immunoassays of toxins or infectious disease agents in war zones, to monitor decontamination procedures or to detect traces of biological agents for treaty verification. This proposal suggests the development of a compact, diode laser-based biosensor that can be used in war zones and in compliance monitoring. The innovation of the proposed system is the combination of sensitive diode laser-based methods of excitation with near-infrared saturable absorber-tagged immunological or DNA hybridization probes to provide a sensor having unparalleled sensitivity to biological warfare agents and toxins. The Phase I technical objectives include selection of label materials, design and fabrication of the diode laser-based instrumentation, immobilization of fluorophores on waveguide structures, fabrication of modular photodetection elements and electronic components, and acquisition of families of test data for use in optimization of a proof-of-concept prototype system.

* information listed above is at the time of submission.

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