GOOD RECOVERY OF MOTOR FUNCTION FOLLOWING SEVERE DAMAGE TO THE HUMAN NERVOUS SYSTEM, PRIMARILY THE CENTRAL NERVOUS SYSTEM, IS DIFFICULT TO ACHIEVE.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3310
Agency Tracking Number:
3310
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.o. Box 1017 Cooper Station, New York, NY, 10276
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MICHAEL F. ZANAKIS
PRINCIPAL INVESTIGATOR
(212) 475-0732
Business Contact:
() -
Research Institute:
n/a
Abstract
GOOD RECOVERY OF MOTOR FUNCTION FOLLOWING SEVERE DAMAGE TO THE HUMAN NERVOUS SYSTEM, PRIMARILY THE CENTRAL NERVOUS SYSTEM, IS DIFFICULT TO ACHIEVE. THERE MAY BE A NUMBER OF REASONS WHY THE REGENERATIVE RESPONSE TO INJURY WOULD NOT LEAD TO FUNCTIONAL RECOVERY, AND A VARIETY OF METHODOLOGIES HAVE EMERGED TO MANIPULATE THE REGENERATIVE RESPONSE TO INJURY. SUCH METHODOLOGIES INCLUDE MUSCLE TRANSPLANTATION, WHICH IS IMPORTANT IN STUDYING THE REINNERVATION PROCESS, AND IN VITRO TECHNIQUES, UTILIZING A NUMBER OF ELECTROPHYSIOLOGICAL SYSTEMS. THIS PROPOSAL DEALS WITH TESTING THE ABILITY OF A DEVICE TO ATTRACT REGENERATING NEURITES FOR SYNAPTIC CONTACT IN AN IN VITRO PREPARATION. WE WILL ALSO DETERMINE WHETHER IT IS POSSIBLE TO RECORD THE ACTIVITY OF THE ELECTRICALLY EXCITABLE ELEMENTS UPON WHICH SYNAPTIC CONTACT IS MADE. IF THIS FUNCTION OF THE DEVICE CAN BE PARALLELED IN VIVO (SUCH AS IN THE SCIATIC NERVE), THEN IT MAY BE POSSIBLE TO UTILIZE THE ELECTRICAL ACTIVITY OF THE NERVOUS SYSTEM FOR SUBSEQUENT MODULATION OF ELECTRONIC DEVICES (I.E., FOR MUSCLE STIMULATION OR LIMB PROSTHETICS) TO ENABLE THE PARTIAL RESTORATION OF MOTOR CONTROL. IT MAY ALSO BE POSSIBLE TO USE SUCH A COMPATIBLE INTERFACING DEVICE IN PORTIONS OF THE DAMAGED CENTRAL NERVOUS SYSTEM.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government