AND ITS POTENTIAL APPLICATION TO HUMAN HYBRIDOMA TECHNOLOGY.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3009
Amount: $49,593.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
7658 Standish Place, Suite 107, Rockville, MD, 20855
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MICHAEL W. BASELER
 PRINCIPAL INVESTIGATOR
 (301) 294-9553
Business Contact
Phone: () -
Research Institution
N/A
Abstract
AND ITS POTENTIAL APPLICATION TO HUMAN HYBRIDOMA TECHNOLOGY.THIS PROJECT INVOLVES DETERMINING THE ABILITY OF A NEW CLASS OF SYNTHETIC BIOLOGICAL RESPONSE MODIFIERS (BRM) KNOWN AS METHYLFURYLBUTYROLACTONES (MFBL) TO AUGMENT THE PRODUCTION OF LYMPHOKINES (IL-2, B-CELL GROWTH FACTOR, AND IMMUNE INTERFERON) AND MONOKINES (IL-1, PROSTAGLANDINS, AND CYTOLYTIC FACTOR). OUR LABORATORY HAS DETERMINED THAT THE MFBLS ARE POTENT IMMUNOSTIMULATORY COMPOUNDS. MFBLS ARE CAPABLE OF INCREASING THE FOLLOWING IMMUNE FUNCTIONS: 2.PRIMARY AND SECONDARY ANTIBODY PRODUCTION 3.PHAGOCYTOSIS BY BOTH MACROPHAGES AND PMNS. IT IS KNOWN THAT THE ABOVE MENTIONED IMMUNE FUNCTIONS ARE REGULATED IN SOME WAY BY LYMPHOKINES AND/OR MONOKINES. THEREFORE, WE PLAN TO INVESTIGATE THE POSSIBILITY THAT MFBLS ENHANCE THESE IMMUNE FUNCTIONS BY STIMULATING AN INCREASED PRODUCTION OF LYMPHOKINES AND/OR MONOKINES. THIS HYPOTHESIS WILL BE TESTED BOTH IN VIVO AND IN VITRO USING ESTABLISHED MURINE LYMPHOKINE AND MONOKINE ASSAY SYSTEMS.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government