ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3008
Amount: $48,529.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
7658 Standish Place, Suite 107, Rockville, MD, 20855
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PETER E. MAXIM
 PRINCIPAL INVESTIGATOR
 (301) 294-9553
Business Contact
Phone: () -
Research Institution
N/A
Abstract
ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY. DATA ACCUMULATED BY OUR LABORATORIES INDICATE THAT THE METHYLFURYLBUTYROLACTONE (MFBL) CLASS OF COMPOUNDS REPRESENTS NEW SYNTHETIC IMMUNE RESPONSE MODIFIERS CAPABLE OF ACTIVATING SEVERAL COMPONENTS OF IMMUNE RESPONSE WITH NEGLIGIBLE TOXICITY TO THE HOST. THIS PROPOSAL DESCRIBES RESEARCH DESIGNED TO ANALYZE ONE ASPECT OF THE IMMUNOSTIMULATORY ACTIVITY OF MFBLS, THE ABILITY TO STIMULATE ANTIBODY PRODUCTION. PHASE I RESEARCH WILL CONCENTRATE ON THE OPTIMIZATION OF TREATMENT REGIMENS AND THE EVALUATION OF THE RANGE OF ACTIVITY OF THE DRUGS TOWARD THE PRIMARY AND SECONDARY ANTIBODY RESPONSE TO T-DEPENDENT AND T-INDEPENDENT ANTIGENS. WE FURTHER INTEND TO STUDY THE EFFECT OF MFBL IN VIVO ON THE IMPROVEMENT OF THE QUALITY AND QUANTITY OF ANTIBODY PRODUCTION IN MICE AS THAT RELATES TO MONOCLONAL ANTIBODY TECHNOLOGY. IN ADDITION, WE WILL ASSESS MURINE IN VITRO ANTIGEN SENSITIZATION

* Information listed above is at the time of submission. *

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