INTERFACE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4784
Agency Tracking Number:
4784
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
7658 Standish Place, Suite 107, Rockville, MD, 20855
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ROBERT W VELTRI
PRINCIPAL INVESTIGATOR
(301) 294-9553
Business Contact:
() -
Research Institute:
n/a
Abstract
A MAJOR OBJECTIVE OF THIS STUDY IS TO INVESTIGATE THE UTILITY OF A NEW AND INNOVATIVE LIQUID MICROCARRIER (MC) SYSTEM FOR CLONING AND PROPAGATING HUMAN TUMOR CELLS IN VITRO. THIS NEW PATENTED TECHNOLOGY IS AN OIL EMULSION OF DEFINED DROPLET SIZE (100 TO 200 MM) HAVING A SMOOTH, PLIABLE, AND TRANSPARENT SURFACE. THE PROTEIN AT THE OIL EMULSION INTERFACE CAN DIRECTLY SUPPORT THE GROWTH OF TRANSFORMED CELLS, OR THESE LAYERS CAN BE DESIGNED TO CONTAIN PROTEINS IMPORTANT TO THE ATTACHMENT AND SPREADING OF NORMAL OR MALIGNANTLY TRANSFORMED CELLS. ABC, LTD., WILLPREPARE MC OIL EMULSION MICROCARRIERS CONDUCTIVE TO THE ATTACHMENT AND GROWTH OF HUMAN TUMOR CELLS IN THIS PHASE I PROJECT. THE NEW MC SYSTEM WILL BE COMPARED TO THE CURRENT TWO-LAYER SOFT AGAR CLONING METHODOLOGY USING PRIMARY TISSUE SAMPLES OBTAINED FROM PATIENTS AT SURGERY. THE PROTOTYPE OIL EMULSION MC WILL BE OF VALUE TO CLONING AND PROPAGATING PRIMARY HUMAN TUMORS FOR USE IN CHEMOSENSITIVITYASSAYS. IN ADDITION, THIS TECHNOLOGY CAN PROVIDE A SOURCE OF TUMOR CELL ANTIGENS FOR PREPARING MONOCLONAL ANTIBODIES FOR TUMOR-SPECIFIC IMMUNOTHERAPY. PHASE II WILL INVOLVE THEAPPLICATION OF THE MC TECHNOLOGY TO THE THERAPEUTIC APPLICATIONS STATED IN THE AREAS OF CHEMOSENSITIVITY AND IMMUNOTHERAPY.

* information listed above is at the time of submission.

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