EVALUATION OF THE IMMUNE MODULATOR MFBL FOR ANTIVIRAL EFFICACY

Award Information
Agency:
Department of Defense
Branch
Navy
Amount:
$495,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
5467
Agency Tracking Number:
5467
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
7658 Standish Pl - Ste 107, Rockville, MD, 20855
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Peter E Maxim
(301) 294-9553
Business Contact:
() -
Research Institute:
n/a
Abstract
THE METHYLFURYLBUTYROLACTONES (MFBL'S) ARE A UNIQUE GROUP OF CHEMICAL COMPOUNDS THAT COMPRISE A NEW GROUP OF SYNTHETIC IMMUNOMODULATORS. THE COMPOUNDS ARE WATER SOLUBLE, RELATIVELY NON-TOXIC, ECONOMICAL TO PRODUCE IN QUANTITY, AND EFFECTIVE WHEN ADMINISTERED VIA THE INTRAVENOUS, INTRAPERITONEAL OR ORAL ROUTES. THE DRUGS HAVE BEEN SHOWN TO POSSESS A WIDE RANGE OF IMMUNOMODIFYING PROPERTIES. MURINE SPLENOCYTES FROM DRUG TREATED ANIMALS ARE: MORE RESPONSIVE TO MITOGENS AND ANTIGENS IN LYMPHOCYTE PROLIFERATION ASSAY, RESPOND TO IN VITRO STIMULATION BY PRODUCING LARGE QUANTITIES OF INTERLEUKIN-2 AND GAMMA INTERFERON AND RESPOND TO T-DEPENDENT ANTIGEN CHALLENGE BY PRODUCING LARGER QUANTITIES OF ANTIBODY FORMING CELLS. THE DRUGS ALSO HAVE BEEN SHOWN TO FUNCTION TO STIMULATE HOST FIRST LINE DEFENSE AGAINST BACTERIA BY ACTIVATING POLYMORPHONUCLEAR ANTIBACTERIAL ACTIVITY. A STUDY TO EVALUATE THE FEASIBILITY OF USING MFBL'S AS THERAPEUTIC AND PROPHYLACTIC ANTIVIRAL AGENTS IS DESCRIBED IN THIS PROPOSAL. USING A WELL-DEFINED MODEL SYSTEM, ACUTE AND CHRONIC INFECTION OF MICE WITH LYMPHOCYTIC CHORIOMENINGITIS VIRUS, THE ABILITYOF MFBL TO MODIFY CRITICAL HOST ANTIVIRAL EFFECTOR MECHANISMS WILL BE EVALUATED.

* information listed above is at the time of submission.

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