A NEW CHROMOSOME BAND-SPECIFIC IDENTIFICATION METHOD

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19275
Amount: $426,212.00
Phase: Phase II
Program: SBIR
Awards Year: 1994
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
C P Li Biomedical
2000 North 14th Street, Suite 740, Arlington, VA, 22201
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Han-xiang Deng
 (703) 558-3400
Business Contact
Phone: () -
Research Institution
N/A
Abstract
WE WILL DEVELOP A SIMPLE CHROMOSOME BAND-SPECIFIC PAINTING TECHNIQUE, WITH THE DIRECT USE OF PCR PRODUCTS FROM MICRODISSECTED DEFINED CHROMOSOMAL REGION AS A POOL OF PROBES. THE TECNIQUE WILL BE STANDARDIZED AND WILL BE FURTHER TESTED DURING THE PHASE II PERIOD. AFTER THE TECHNIQUE/KIT IS FULLY DEVELOPED, IT WILL ALLOW THE MEDICAL PROFESSION TO IDENTIFY GENETIC ABERRRATIONS OF NEWBORNS; TO STUDY NEUROMUSCULAR DISORDERS; AND HAVE BETTER UNDERSTANDINGS WITH DISEASES SUCH AS PARKINSON'S, HUNTINGTON'S AND ALZHEIMER'S DISEASES. THIS NEW TECHNIQUE WILL ENABLE THE RESEARCH SCIENTISTS TO STUDY THE ORIGIN OF CYTOGENETICALLY UNIDENTIFIABLE MARKER CHROMOSOMES AS WELL. OUR NEW METHOD WILL PROVIDE US THE MEANS TO CONSTRUCT PROBES THAT ARE SPECIFIC FOR EVERY METAPHASE CHROMOSOME BAND OF THE HUMAN GENOME, AND TO GENERATE BAND-SPECIFIC PROBE POOL IN LESS THAN TWO DAYS. THE USE OF OUR TECHNIQUE/PRODUCT PERTAINS TO STUDY OF GENETIC DISEASES OF THE NEWBORNS AND CHILDREN, AS WELL AS THE DIAGNOSIS OF COMMON DISEASES OF THE AGED. THE FUTURE MARKETING POSSIBLE IS UNLIMITED, WORLDWIDE.

* information listed above is at the time of submission.

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