NON-ISOTOPIC MONOCLONAL IMMUNOASSAY FOR FENTANYL ANALOGS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 8134
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Box 68505, Indianapolis, IN, 46268
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG TERM OBJECTIVE IS TO DEVELOP A HIGHLY AUTOMATED FLUORESCENCE POLARIZATION IMMUNOASSAY (FPIA) FOR FENTANYL AND ANALOGS. THE PHASE I SPECIFIC AIM IS TO SYNTHESIZE AND EVALUATE: 1) FLUORESCEIN LABELED FENTANYL ANALOGS USABLE IN A FPIA; 2) FENTANYL (HAPTEN) - PROTEIN CONJUGATES USED TO ELICIT AN IMMUNE RESPONSE IN BALB/C MICE; 3) MURINE MONOCLONAL ANTIBODIES TO FENTANYL AND ANALOGS. THE PHASE I OBJECTIVE IS TWOFOLD: 1) TO CHOOSE FROM THE SYNTHETIC COMPONENTS A BEST COMBINATION FOR MEASURING FENTANYL AND ANALOGS; 2) TO PREPARE A SMALL "BANK" OF WELL CHARACTERIZED MURINE MONOCLONAL ANTIBODIES FOR INTERNAL USE AS WELL AS FOR USE BY OTHER INVESTIGATORS. THE HEALTHCARE INDUSTRY AND LEGISLATORS ARE ILL PREPARED FORTHE RAPID AND COMPLEX IMPACT OF ESCALATING FENTANYL ABUSE. THE NEED OF AN INNOVATIVE APPROACH FOR DETECTING FENTANYL INBLOOD OR URINE IS GENERALLY RECOGNIZED. AUTHORITIES AGREE THAT AN IMMUNOASSAY WILL BE REQUIRED. BY PROVIDING A FLUORESCENCE POLARIZATION IMMUNOASSAY FOR FENTANYL AND ANALOGS, THE DRAWBACKS ASSOCIATED WITH RADIOIMMUNOASSAY WILL BE OVERCOME.

* Information listed above is at the time of submission. *

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