ELECTROSPRAY TIME-OF-FLIGHT MASS SPECTROMETRY WITH PRC

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 11273
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1989
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Analytica Of Branford Inc
29 Business Park Dr, Branford, CT, 06405
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
AN ELECTROSPRAY (ES) ION SOURCE WILL BE INTERFACED TO A TIME-OF-FLIGHT (TOF) MASS SPECTROMETER INCORPORATING A PSEUDO-RANDOM-CHOPPING TECHNIQUE. THE TOF MASS SPECTROMETERWILL ALLOW RAPID SCAN RATES AND HIGH-MASS ANALYSIS FOR MULTIPLE AND SINGLY CHARGED IONS DELIVERED FROM THE ES ION SOURCE. USING A PSEUDO-RANDOM-CHOPPING APPROACH FOR OSCILLATING THE ES ION BEAM ACROSS AN ORIFICE INSTEAD OF THE STANDARD PERIODIC CHOPPING PATTERN CAN INCREASE THE DUTY CYCLE POTENTIALLY BY A FACTOR OF 10. THIS INCREASED DUTY CYCLE INCREASES SENSITIVITY PROPORTIONALLY WITHOUT SACRIFICING RESOLUTION. ASSEMBLY OF THE ES-TOF INSTRUMENT AND TESTING OF THE PSEUDO-RANDOM-CHOPPING TECHNIQUE WILL BE CONDUCTED IN PHASE I. THIS INSTRUMENT WILL ALLOW VERY HIGH-MASS ANALYSIS AND ON-LINE LIQUID FEED SYSTEM DETECTION WITH EXTREMELY GOOD SENSITIVITY. WITH ES AS THE INTERFACE, THIS ES-TOF INSTRUMENT CAN BE USED AS A LC/MS OR A CZE/MS ANALYZER. MORE SENSITIVE MS/MS APPLICATIONS COULD BE ACHIEVED WITH THIS ES-TOF INSTRUMENT IN PART DUE TO THE MULTIPLE CHARGING POSSIBLE IN ES.

* information listed above is at the time of submission.

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