ELECTROSPRAY IONIZATION SOURCE--ION MOBILITY ANALYSIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
11270
Agency Tracking Number:
11270
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
29 Business Park Dr, Branford, CT, 06405
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
AN ELECTROSPRAY IONIZATION (ESPI) SOURCE WILL BE INTERFACED WITH AN ION MOBILITY ANALYZER (IMA), AND PERFORMANCE CHARACTERISTICS WILL BE STUDIED. TO ESTABLISH THE POTENTIALFOR COMMERCIALIZATION OF THIS SYSTEM, DETECTION SENSITIVITY LIMITS WILL BE DETERMINED FOR A RANGE OF SAMPLE TYPES. IN ADDITION, THE UPPER MASS RANGE LIMITATIONS OF THE ESPI SOURCE WILL BE EXPLORED, AND ION MOBILITY SPECTRA OF LARGE MACRO-IONS WILL BE STUDIED. OPTIMIZATION OF THE OVERALL INSTRUMENT HARDWARE AND OPERATING PARAMETERS WILL BE DIVIDED INTO FOUR MAJOR TASKS. THE FIRST WILL BE TO OPTIMIZE THE ELECTROSPRAY REGION; SECOND, TO REDESIGN THE PRESENT ESPI/IMA TO ACCOMMODATE THE NECESSARY CHANGES; THIRD, TO OPTIMIZE THE IMA PERFORMANCE USING THE REDESIGNED HARDWARE; AND, FOURTH, TO STUDY THE UPPER MASS LIMIT OF THE ESPI SOURCE. WITH HIGH ENOUGH SENSITIVITY, THE INITIAL COMMERCIAL APPLICATION OF THE ESPI/IMA CAN BE USED AS A DETECTOR SYSTEM FOR LIQUID CHROMATOGRAPHY OR ZONE CAPILLARY ELECTROPHORESIS. USED AS APREFILTER SAMPLE INTRODUCTION ION SOURCE, IT CAN ALSO BE INTERFACED TO A MASS SPECTROMETER ANALYZER.

* information listed above is at the time of submission.

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