ELECTROSPRAY WITH MECHANICAL VIBRATION ASSIST

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
16788
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Analytica Of Branford Inc.
29 Business Park Dr, Branford, CT, 06405
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Shida Shen
(203) 488-8899
Business Contact:
() -
Research Institution:
n/a
Abstract
ELECTROSPRAY IONIZATION COMBINED WITH MASS SPECTROMETRY HAS EVOLVED AS A POWERFUL TECHNIQUE FOR THE ANALYSIS OF A WIDE RANGE OF COMPOUNDS OF INTEREST TO THE FIELD OF MOLECULAR BIOLOGY. THE RESEARCH AIMS TO COMBINE ELECTROSPRAY IONIZATION WITH A MECHANICAL VIBRATION ASSIST. ULTRASONIC NEBULIZERS PRODUCE A DROPLET SIZE PROPORTIONAL TO THE VIBRATIONAL FREQUENCY APPLIED VIRTUALLY INDEPENDENT OF LIQUID FLOW RATE AND THE SOLUTION CHEMISTRIES FOUND IN MOST ELECTROSPRAY APPLICATIONS. THE DROPLETS PRODUCED BY THIS ULTRASONIC NEBULIZATION HAVE A MORE UNIFORM SIZE DISTRIBUTION THAN IS PRODUCED BY PNEUMATIC NEBULIZATION. PRELIMINARY STUDIES HAVE INDICATED THAT BY ASSISTING ELECTROSPRAY WITH ULTRASONIC MECHANICAL VIBRATION, HIGH CONDUCTIVITY, AND HIGH AQUEOUS CONTENT SOLUTIONS CAN BE SPRAYED WITH FLOW RATES RANGING FROM BELOW 1 UL/MIN TO WELL OVER 100 UL/MIN. THE ULTRASONIC VIBRATION ALLOWS THE GENERATION OF A SELECTED DROPLET SIZE INDEPENDENT OF SOLUTION CHEMISTRIES AND ELECTROSPRAY CONDITIONS. PRELIMINARY TESTING INDICATES THAT THIS ASSIST TECHNIQUE WILL SUBSTANTIALLY IMPROVE ELECTROSPRAY PERFORMANCE OVER A WIDER RANGE OF APPLICATIONS, PARTICULARLY WHEN THE ELECTROSPRAY ION SOURCE IS USED IN AN LC/MS INTERFACE. ELECTROSPRAY IONIZATION COMBINED WITH MASS SPECTROMETRY HAS EVOLVED AS A POWERFUL TECHNIQUE FOR THE ANALYSIS OF A WIDE RANGE OF COMPOUNDS OF INTEREST TO THE FIELD OF MOLECULAR BIOLOGY. THE RESEARCH AIMS TO COMBINE ELECTROSPRAY IONIZATION WITH A MECHANICAL VIBRATION ASSIST. ULTRASONIC NEBULIZERS PRODUCE A DROPLET SIZE PROPORTIONAL TO THE VIBRATIONAL FREQUENCY APPLIED VIRTUALLY INDEPENDENT OF LIQUID FLOW RATE AND THE SOLUTION CHEMISTRIES FOUND IN MOST ELECTROSPRAY APPLICATIONS. THE DROPLETS PRODUCED BY THIS ULTRASONIC NEBULIZATION HAVE A MORE UNIFORM SIZE DISTRIBUTION THAN IS PRODUCED BY PNEUMATIC NEBULIZATION. PRELIMINARY STUDIES HAVE INDICATED THAT BY ASSISTING ELECTROSPRAY WITH ULTRASONIC MECHANICAL VIBRATION, HIGH CONDUCTIVITY, AND HIGH AQUEOUS CONTENT SOLUTIONS CAN BE SPRAYED WITH FLOW RATES RANGING FROM BELOW 1 UL/MIN TO WELL OVER 100 UL/MIN. THE ULTRASONIC VIBRATION ALLOWS THE GENERATION OF A SELECTED DROPLET SIZE INDEPENDENT OF SOLUTION CHEMISTRIES AND ELECTROSPRAY CONDITIONS. PRELIMINARY TESTING INDICATES THAT THIS ASSIST TECHNIQUE WILL SUBSTANTIALLY IMPROVE ELECTROSPRAY PERFORMANCE OVER A WIDER RANGE OF APPLICATIONS, PARTICULARLY WHEN THE ELECTROSPRAY ION SOURCE IS USED IN AN LC/MS INTERFACE.

* information listed above is at the time of submission.

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