Electrospray Ion Trap Time of Flight Mass Spectrometry

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$532,175.00
Award Year:
1996
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 MH52510-1,
Agency Tracking Number:
25195
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Analytica Of Branford, Inc.
29 Business Park Drive, Branford, CT, 06405
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
James Boyle
(203) 488-8899
Business Contact:
() -
Research Institution:
n/a
Abstract
A novel combination of techniques is proposed as a mass detector for biological compounds.A quadruple ion trap is used as a storage device for ions introduced from an Electrospray ionizationsource, thereby providing 100% duty cycle, while a reflection time-of-flight mass spectrometer is usedfor the rapid and highly sensitive mass analysis of ion bunches expelled from the ion trap on asub-second time frame. This instrument would be ideally suited as a high sensitivity detector for variousseparations systems. Its ability to effectively mediate samples between a continuous ion source and apulsed mass analyzer without requiring expensive detection electronics would be a performancebreakthrough, providing an important analytical method in a potentially inexpensive MS package. Sucha hybrid instrument would have the capability of providing highly accurate molecular weight andstructural information for a wide variety of biological compounds, while at the same time possessingsensitivity characteristics currently unattainable on either dispersive or even other time-of-flightplatforms. A low cost, modular approach will be used to demonstrate this technology on an existingElectrospray TOF instrument, optimizing sensitivity and mass resolution by using a gridless ion mirror.A minimal control strategy will be adopted to remove operational complexity and afford access tonon-MS Arts with a wide variety of analytical backgrounds.

* information listed above is at the time of submission.

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