Electrospray Ion Trap Time of Flight Mass Spectrometry

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 MH52510-1,
Agency Tracking Number: 25195
Amount: $532,175.00
Phase: Phase II
Program: SBIR
Awards Year: 1996
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Analytica Of Branford, Inc.
29 Business Park Drive, Branford, CT, 06405
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 James Boyle
 (203) 488-8899
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A novel combination of techniques is proposed as a mass detector for biological compounds.A quadruple ion trap is used as a storage device for ions introduced from an Electrospray ionizationsource, thereby providing 100% duty cycle, while a reflection time-of-flight mass spectrometer is usedfor the rapid and highly sensitive mass analysis of ion bunches expelled from the ion trap on asub-second time frame. This instrument would be ideally suited as a high sensitivity detector for variousseparations systems. Its ability to effectively mediate samples between a continuous ion source and apulsed mass analyzer without requiring expensive detection electronics would be a performancebreakthrough, providing an important analytical method in a potentially inexpensive MS package. Sucha hybrid instrument would have the capability of providing highly accurate molecular weight andstructural information for a wide variety of biological compounds, while at the same time possessingsensitivity characteristics currently unattainable on either dispersive or even other time-of-flightplatforms. A low cost, modular approach will be used to demonstrate this technology on an existingElectrospray TOF instrument, optimizing sensitivity and mass resolution by using a gridless ion mirror.A minimal control strategy will be adopted to remove operational complexity and afford access tonon-MS Arts with a wide variety of analytical backgrounds.

* information listed above is at the time of submission.

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