RECEPTOR BINDING AND ENZYME ASSAYS USING BIOSOMES TM

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
1997
Program:
SBIR
Phase:
Phase I
Contract:
GM57154-01
Award Id:
39180
Agency Tracking Number:
39180
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Analytical Biological Services (Currently ANALYTICAL BIOLOGICAL SERVICES, INC.)
CORNELL BUSINESS PARK 701-4, Wilmington, DE, 19801
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
SALLER, CHARLES F
() -
Business Contact:
(302) 654-4492
Research Institution:
n/a
Abstract
The proposed research is aimed at developing a new molecular recognition technology for drug discovery. Stable liposome-based biosensors, called Biosomes TM, turn from blue to red in response to a specific molecular recognition event. The Biosomes can be functionalized with a specific receptor ligand or enzyme substrate so that they respond specifically to a particular receptor or enzyme. Our aim is to develop either a prototypic receptor binding or enzyme assay using the Biosome TM technology in high- throughput screening to detect potential drug leads. In Phase II, this technology will be expanded to additional receptor and enzyme assays of interest to the pharmaceutical industry. These assays will have the advantage of being rapid, homogeneous and non-radioactive. Specifically, we will examine stability and specificity of the Biosomes TM, optimize the assays to detect inhibitors, and determine reproducibility and reliability of the assays. This proposal will enable the development of a new technology which should contribute to the discovery of drugs for a broad range of diseases including psychiatric disorders, inflammatory diseases and cancer.

* information listed above is at the time of submission.

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