Fluorescent Coated Filters for Detection of Biological Warfare Agent Microorganisms in Water

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-04-C-0132
Agency Tracking Number: A2-1327
Amount: $749,694.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: ARMY02-T009
Solicitation Number: N/A
Timeline
Solicitation Year: 2002
Award Year: 2004
Award Start Date (Proposal Award Date): 2004-09-20
Award End Date (Contract End Date): 2005-09-19
Small Business Information
701-4 Cornell Business Park, Wilmington, DE, 19801
DUNS: 612501502
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mary Reppy
 Director of Chemical Research
 (302) 654-4492
 reppy@absbio.com
Business Contact
 Rachel Stahl
Title: Senior Contracts Administrator
Phone: (650) 859-4694
Email: rachel.stahl@sri.com
Research Institution
N/A
Abstract
Reliable and sensitive detection of biowarfare agents (BWAs) such as Bacillus anthracis, Yersinia pestis, Francisella tularensis, ricin, botulinum toxin, etc. is an important challenge for both military operations and domestic anti-terrorism efforts. We are proposing to develop a biomimetic polymer coating, containing receptors for BWA targets, that becomes fluorescent when exposed to samples containing BWAs. The polymer will be coated onto filter membranes in a cartridge that can be read by a portable fluorescence detector. The proposed detection system will allow rapid and easy parallel testing of aqueous samples such as drinking supplies, water trapped aerosols or swab samples, for multiple BWAs. The coated filters will concentrate microorganisms and then become fluorescent as the targets bind to the receptors; with appropriate receptors the coatings can also detect toxins. In Phase I, we developed polymer/antibody coatings, detected Bacillus cereus spores as an anthrax simulant, performed appropriate control experiments, and designed the detection unit. In Phase II we will prepare coated filters for the detection of several biowarfare microorganisms and toxins with increased sensitivity, and build a prototype unit for detecting multiple targets in parallel.

* Information listed above is at the time of submission. *

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