COMPOSITE, HOLLOW FIBER MEMBRANE OXYGENATION DEVICE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$461,350.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
7304
Agency Tracking Number:
7304
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1280 Dussel Drive, Maumee, OH, 43537
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Don N Gray Phd
(419) 891-3030
Business Contact:
() -
Research Institute:
n/a
Abstract
THE ACCEPTANCE OF EXTRACORPOREAL OXYGENATION DEVICES BASED ON GAS TRANSFER THROUGH A MEMBRANE WILL DEPEND TO A LARGE EXTENT ON THE AVAILABILITY OF SIMPLER, EASIER TO USE, SAFER,AND LOWERCOST DEVICES. OXYGENATORS USING MICROPOROUS HOLLOWFIBERS HAVE COME INTO WIDER USE THE LAST FIVE YEARS. THEY PRESENT MORE MEMBRANE SURFACE TO BLOOD AND GAS PHASES FOR EQUIVALENT VOLUME AND DO NOT REQUIRE A SUPPLEMENTAL SECONDARY FLOW FOR ADEQUATE GAS TRANSFER. THESE DEVICES DO,HOWEVER, SUFFER FROM THE REAL AND POTENTIAL PROBLEMS ASSOCIATED WITH ALL MEMBRANE OXYGENATORS MADE FROM MICROPOROUS MATERIALS-POSSIBLE BLOOD DAMAGE DUE TO MICROBUBBLE INTRUSION, EXCESSIVE WATER TRANSPORT AND SEEPAGE, AND A LACK OF SELECTIVITY IN EXCHANGING OXYGEN AND CARBON DIOXIDE. THIS PROPOSAL SUGGESTS AN IMPROVEMENT TO THE PRESENT STATE-OF-THE-ART, MICROPOROUS-BASED HOLLOW-FIBER OXYGENATORSTHAT ELIMINATES ALL THE ABOVE PROBLEMS BY DEVELOPING A COMPOSITE PERMSELECTIVE/MICROPOROUS HOLLOW FIBER DEVICE OF OPTIMUM GEOMETRY AND MEMBRANE CHARACTERISTICS. THE OPTIMIZED HOLLOW-FIBER GEOMETRY WILL BE COMBINED WITH PAS MATERIALS THAT HAVE BEEN SHOWN TO HAVE SUPERIOR PERMEABILITYTO CARBON DIOXIDE AND OXYGEN AND HIGH BIOCOMPATIBILITY WITH BLOOD.

* information listed above is at the time of submission.

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