GLYCATED HEMOGLOBIN BY AUTOMATED AFFINITY CHROMATOGRAPHY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$453,807.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
7305
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Anatrace Inc.
1280 Dussel Drive, Maumee, OH, 43537
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Melvin H Keyes Phd
(419) 891-3030
Business Contact:
() -
Research Institution:
n/a
Abstract
CLASSICAL ASSAYS FOR DETERMINING BLOOD AND URINE GLUCOSE HAVE LIMITED VALUE FOR THE MONITORING OF AN INDIVIDUAL'S BLOOD GLUCOSE LEVEL OVER TIME. MEASUREMENT OF GLYCATED HEMOGLOBIN (GHB) IS ALREADY GAINING ACCEPTANCE FOR MANAGEMENT OF PERSONS WITH DIABETES MELLITUS. GHB LEVELS ARE NOT ONLY USEFUL FOR DIAGNOSIS BUT ALSO FOR THE ESTABLISHMENT OF CARE GOALS AND FOR CARE REINFORCEMENT. IN THE FUTURE, MORE PHYSICIANS WILL USE GHB MEASUREMENTS FOR THE ROUTINE MANAGEMENT OF DIABETES, AND THIS WILL REQUIRE MORE RELIABLE AND COST-EFFECTIVE TEST METHODOLOGIES. ANATRACE, INC. PROPOSES TO DEVELOP A SEMI-AUTOMATED INSTRUMENT FOR MEASUREMENT OF GHB THAT WILL REDUCE HUMAN ERROR. THE HEART OF THE INSTRUMENT IS AN AFFINITY SUPPORT THAT WILL POSSESS SUFFICIENT LIGAND SIDE CHAINS AND HAVE EXCELLENT FLOW PROPERTIES. THE OBJECTIVE OF PHASE I IS THE DEVELOPMENT OF THIS AFFINITY SUPPORT.

* information listed above is at the time of submission.

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