THROMBORESISTANT MATERIAL FOR EXTRACORPOREAL DEVICES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$749,427.00
Award Year:
1996
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
19301
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Anatrace Inc.
1280 Dussel Drive, Maumee, OH, 43537
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Don N Gray
(419) 891-3030
Business Contact:
() -
Research Institution:
n/a
Abstract
THE USE OF EXTRACORPOREAL, BASED THERAPIES CONTINUES TO GROW (DIALYSIS, EMO, PHERISIS, DETOXIFICATION, ETC). IN EVERY CASE THE USE OF EXTRACORPOREAL CIRCULATION REQUIRES SYSTEMIC ANTICOAGULATION TO PREVENT THROMBOSIS. HEPARIN HAS BEEN THE STANDARD ANTICOAGULANT USED AND IS SAFE AND EFFECTIVE IN MOST INSTANCES; HOWEVER, THE USE OF HEPARIN MAY BE ASSOCIATED WITH ADVERSE SIDE EFFECTS SUCH AS THROMBOCYTOPENIC AND HEMORRHAGE. MEMBRANE OXYGENATION IN NEONATES, A SUCCESSFUL AND GROWING TREATMENT, CAN CAUSE INTRACRANIAL HEMORRHAGE BECAUSE OF HEPARIN USE. PAST AND ONGOING WORK BY THE APPLICANT ORGANIZATION ON POLYALKYLSULFONE POLYMERS (BIOBLAND (R)) HAVE BEEN DIRECTED TO COATING HOLLOW FIBERS WITH ONE MEMBER OF THIS FAMILY (BIOBLAND-16 (R)). THIS POLYMER COATING HAS HIGH GAS PERMEABILITY AND EXCELLENT BIOCOMPATIBILITY. WE WILL MODIFY THIS POLYMER VIA COPOLYMERIZATION WITH FUNCTIONALLY ACTIVE MONOMERS, TO FORM MOLECULAR STRUCTURES AMENABLE TO FURTHER DERIVATIZATION TO YIELD PHARMACEUTICALLY ACTIVE NON-THROMBOGENIC SURFACES.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government