Synthesis and Characterization of Amphipatic Polymers

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$391,813.00
Award Year:
2001
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
2R44GM060071-02
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ANATRACE, INC.
1280 DUSSEL DR, MAUMEE, OH, 43537
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MELVIN KEYES
() -
Business Contact:
(419) 891-3030
Research Institution:
n/a
Abstract
DESCRIPTION: (provided by applicant) Ainphipols are low molecular weight (<20 kDa) linear polymers having a distribution of polar and hydrophobic side chains which confers amphipaticity to the polymer. Amphipols represent a unique way of solubilizing integral membrane proteins. Amphipols wrap themselves around the hydrophobic transmembrane domains of membrane proteins so that the hydrophobic side chains of the polymer stabilize the hydrophobic surface of the protein, while the polar side chains of the polymer confer aqueous solubility to the protein-amphipol complex In Phase I a new and simpler route to the only existing family of amphipols was developed and an entirely new and potentially useful family of amphipols was discovered. In Phase II we plan to synthesize and characterize a number of variations of this family (called PMALT). These new molecules will be evaluated in the laboratory of Dr. Charles R. Sanders for their ability to solublize, stabilize, and maintain the functionality of membrane proteins. The study will provide the basis for future unique applications of amphipols in structural biology biochemistries, biomedicine, and biotechnology. PROPOSED COMMERCIAL APPLICATION: The possibility of using the materials proposed here to study membrane protein structure in solution via NMR is especially appearing. Amphipols may also provide the basis for new approaches in drug delivery, biosensors, and other biomedical/ technological applications. Presently, there is no commercial source for amphipol- class polymers. Anatrace has a history of timely introduction of new, useful detergent and other biochemicals to the international technical community.

* information listed above is at the time of submission.

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