Synthesis and Optimization of a Malaria Vaccine

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$130,750.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI058535-01
Agency Tracking Number:
AI058535
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ANCORA PHARMACEUTICALS
ANCORA PHARMACEUTICALS, 700 HURON AVE, #18K, CAMBRIDGE, MA, 02138
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
OBADIH PLANTE
(781) 395-7700
OPLANTE@ANCORAPHARMA.COM
Business Contact:
JOHN PENA
(617) 354-0863
JPENA@ANCORAPHARMA.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Plasmodium falciparum malaria infects 5-10% of the global population (400 million clinical cases) and kills two million people annually. As such it ranks along with HIV and TB as the most serious infectious disease of humanity. It is widely accepted that an efficacious vaccine is required to afford protection against malarial fatalities. Recent research demonstrates the feasibility of a carbohydrate molecule-based Malaria vaccine approach. Scientific evidence shows that a glycosylphosphatidylinositol (GPI) molecule, a glycolipid-related carbohydrate, of Malarial parasite origin utilized as a vaccine can prevent the pathology and fatalities in rodent models of severe malaria. Three critical parameters to be considered in the generation of the optimal Malaria Vaccine molecule include: the identification of the minimal immunogenic molecule sequence that determines the specificity of immune response; the capability to generate sufficient material quantities for the requisite pre-clinical trials; and, the appropriate protein conjugate and adjuvant to potentiate the immune response. The goal of this SBIR proposal is to develop the synthesis strategy for large-scale molecule preparation and to generate a set of vaccine molecules that will help elucidate the lead vaccine molecule for subsequent advanced pre-clinical trials.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government