Circulating Prostate Cancer Progenitor Cell Assay Development

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$96,765.00
Award Year:
2008
Program:
STTR
Phase:
Phase I
Contract:
W81XWH-08-C-0099
Award Id:
85077
Agency Tracking Number:
A08A-041-0388
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
73 High Street, Buffalo, NY, 14203
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
193493157
Principal Investigator:
MichaelZwick
CEO
(716) 860-7920
mzwick@androbiosys.com
Business Contact:
MichaelZwick
CEO
(716) 860-7920
mzwick@androbiosys.com
Research Institute:
ROSWELL PARK CANCER INSTITUTE
Joseph H Jurkowski
Elm and Carlton Streets
Buffalo, NY, 14263
(716) 845-2312
Domestic nonprofit research organization
Abstract
This Phase I contract proposal will evaluate and identify markers associated with prostate cancer progenitor stem cells, that differentiate these cells from adult tissue stem cells and benign prostate progenitor cells. The eventual goal of this work would be to develop a high throughput blood-based assay highly specific for circulating prostate cancer progenitor cells. A cell shed from a tumor must be capable of surviving separate from the microenvironment of the primary tumor, and possess the capacities of proliferation and plasticity, to regenerate a metastasis. These traits essentially describe a cancer stem cell (CSC). Therefore, we propose to develop a technology to identify circulating CSCs, or more accurately the progenitor cells that are their immediate progeny, an approach that should provide a more informative prognostic tool for prediction of aggressiveness and metastatic potential.

* information listed above is at the time of submission.

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