MECHANISM-BASED ELASTASE INHIBITORS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7306
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Andrulis Research Corp
7315 Wisconsin Avenue, Suite 650n, Bethesda, MD, 20814
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 CLARE BISWAS PHD
 (301) 657-1700
Business Contact
Phone: () -
Research Institution
N/A
Abstract
SYNTHETIC ELASTASE INHIBITORS FOR USE IN THE TREATMENT OF EMPHYSEMA WILL BE DEVELOPED. IN PHASE I, NEW MECHANISM-BASED ELASTASE INHIBITORS WILL BE SYNTHESIZED, CHARACTERIZED, AND STUDIED AS INHIBITORS OF ELASTASE IN VITRO. THESE INHIBITION STUDIES WILL ANALYZE BOTH THE REVERSIBLE BEHAVIOR OF THE INHIBITORS AND THE TIME-DEPENDENT, IRREVERSIBLE ELASTASE INACTIVATION. AFTER THE CHEMISTRY OF THE ELASTASE INACTIVATION HAS BEEN ELUCIDATED IN PHASE I, A STRUCTURE-ACTIVITY STUDY WILL BE CARRIED OUT IN PHASE II TO DEVELOP THE MOST POTENT ELASTASE INHIBITORS. BECAUSE THE ABSENCE OF NATURAL ELASTASE INHIBITORS IN THE LUNG IS BELIEVED TO BE RESPONSIBLE FOR MUCH OF THE PATHOGENESIS OBSERVED IN EMPHYSEMA, THESE NEW SYNTHETIC ELASTASE INHIBITORS SHOULD BE VERY VALUABLE FOR USE IN REPLACEMENT THERAPY FOR PATIENTS WITH EMPHYSEMA.

* information listed above is at the time of submission.

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