MECHANISM-BASED ELASTASE INHIBITORS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7306
Agency Tracking Number:
7306
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
7315 Wisconsin Avenue, Suite 650n, Bethesda, MD, 20814
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
CLARE BISWAS PHD
(301) 657-1700
Business Contact:
() -
Research Institute:
n/a
Abstract
SYNTHETIC ELASTASE INHIBITORS FOR USE IN THE TREATMENT OF EMPHYSEMA WILL BE DEVELOPED. IN PHASE I, NEW MECHANISM-BASED ELASTASE INHIBITORS WILL BE SYNTHESIZED, CHARACTERIZED, AND STUDIED AS INHIBITORS OF ELASTASE IN VITRO. THESE INHIBITION STUDIES WILL ANALYZE BOTH THE REVERSIBLE BEHAVIOR OF THE INHIBITORS AND THE TIME-DEPENDENT, IRREVERSIBLE ELASTASE INACTIVATION. AFTER THE CHEMISTRY OF THE ELASTASE INACTIVATION HAS BEEN ELUCIDATED IN PHASE I, A STRUCTURE-ACTIVITY STUDY WILL BE CARRIED OUT IN PHASE II TO DEVELOP THE MOST POTENT ELASTASE INHIBITORS. BECAUSE THE ABSENCE OF NATURAL ELASTASE INHIBITORS IN THE LUNG IS BELIEVED TO BE RESPONSIBLE FOR MUCH OF THE PATHOGENESIS OBSERVED IN EMPHYSEMA, THESE NEW SYNTHETIC ELASTASE INHIBITORS SHOULD BE VERY VALUABLE FOR USE IN REPLACEMENT THERAPY FOR PATIENTS WITH EMPHYSEMA.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government