ENDOSCOPIC LIGHT SOURCE FOR PDT

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: PHS2001-2
Agency Tracking Number: 2R42RR012259-02A1
Amount: $278,132.00
Phase: Phase II
Program: STTR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
508 HEARTWOOD RD, CHERRY HILL, NJ 08003, CHERRY HILL, NJ, 08003
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 RICHARD HSI
 (215) 346-5570
 HSI@XRT.UPENN.EDU
Business Contact
Phone: (609) 795-4560
Email: AMTINCOFDE@AOL.COM
Research Institution
 UNIVERSITY OF PENNSYLVANIA
 UNIVERSITY OF PENNSYLVANIA
PHILADELPHIA, PA, 19152
 Nonprofit college or university
Abstract
DESCRIPTION (Verbatim from the Applicant's Abstract): We propose to continue to develop and test a self-contained light delivery device for use in photodynamic therapy (PDT) for Barrett's esophagus. This device employs distally located semiconductor lasers at the end of a thin coaxial cable inserted into a balloon catheter. In Phase I, we successfully developed prototype units that produced sufficient light for PDT treatment and evaluated different scattering media to increase the uniformity of the light emission. In Phase II, we intend to design enhancements that produce uniform light distribution and increase the illuminator's flexibility. A light and fluorescence detection system will be incorporated into the balloon's wall. Unit will be tested for safety and efficacy in an animal model. A significant advantage to this source design is that individual segments or spot locations across the illuminator can be turned on or off and the intensity changed during treatment. The light and fluorescence detection systems will allow more uniform treatment and help optimize treatment parameters (fluence, fluence rate, photosensitizer dose, and photosensitizer/light interval) to maximize the PDT effect and minimize toxicity. The diode illuminator will be capable of changing light dosing parameters to fit optimal conditions for any situation including the use of different photosensitizing compounds. PROPOSED COMMERCIAL APPLICATION: Not Available

* Information listed above is at the time of submission. *

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