Anti-apoptotic Mechanism of SF/HGF Mimetics

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AA014718-01
Agency Tracking Number: AA014718
Amount: $191,709.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (516) 562-1124
Business Contact
Phone: (516) 869-6400
Research Institution
DESCRIPTION (provided by applicant): Apoptotic cell loss triggered by ischemia-reperfusion plays a prominent role in delayed graft function and acute renal failure following kidney transplant. In experimental models of ischemia-reperfusion, treatment with scatter factor/hepatocyte growth factor reduced renal dysfunction and accelerated renal regeneration, in part by attenuating apoptotic cell death. Using phage display technology and molecular modeling we recently identified C6, a small molecule compound, which exhibits scatter factor/hepatocyte growth factor-like cytoprotective effects. Small pilot studies suggest that the anti-apoptotic effect of C6 is mediated by nitric oxide. By delineating the signaling pathways involved in C6 cytoprotection, the proposed SBIR Phase I application can lead to the development of new C6 analogs that specifically target these pathways, maximizing therapeutic potential while minimizing the risk of any side effects. These studies are expected to provide sufficient supporting data for more in depth Phase II studies with the ultimate goal of bringing this compound or other more potent and easily deliverable compounds into clinical trials for the treatment of renal failure.

* Information listed above is at the time of submission. *

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