PRAS-AST: A NOVEL ANAEROBIC SUSCEPTIBILITY TEST

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$154,218.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI050993-01
Award Id:
60442
Agency Tracking Number:
AI050993
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ANAEROBE SYSTEMS, INC. (Currently ANAEROBE SYSTEMS INC)
ANAEROBE SYSTEMS, INC., 15906 CONCORD CIR, MORGAN HILL, CA, 95037
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MIKE COX
(408) 782-7557
MIKECOX@ANAEROBESVSTEMS.COM
Business Contact:
MIKE COX
(408) 782-7557
MIKECOX@ANAEROBESYSTEMS.COM
Research Institution:
n/a
Abstract
Clinical susceptibility testing of anaerobes has long been complicated by the lack of reproducible growth and prolonged incubation times. Adding to the complexity, antibiotic resistance in anaerobes is a growing and unpredictable problem. We hypothesize that current growth inconsistencies and culture difficulties will prove to result from preparation of media and inocula under aerobic conditions. Anaerobe Systems proposes to mitigate the difficulties in growth and MIC (Minimal Inhibitory Concentration) determinations for anaerobes by developing a complete system that provides rapid, reliable growth and reproducible MICs. Performance of the prototype and technique will be determined in steps defined by three specific aims. Specific Aim I will determine optimal growth conditions by comparing growth from inoculum and media handled completely anaerobically versus the current method in which the medium and inoculum are prepared and stored aerobically. We will test multiple strains of 15 clinically relevant anaerobes and 3 quality control anaerobes. Specific Aim II will compare the MlCs of the clinical isolates against 12 antibiotics under the conditions outlined above, evaluating performance based on NCCLS standards. Specific Aim Ill will test the manufacturing, performance, and stability of the test prototype by Anaerobe Systems and external consultants.

* information listed above is at the time of submission.

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