MONOCLONAL ANTIBODIES AGAINST THE MHC OF INBRED RATS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7375
Agency Tracking Number:
7375
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
628-g Lofstrand Lane, Rockville, MD, 20850
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HAROLD A HOFFMAN PHD
(301) 251-1101
Business Contact:
() -
Research Institute:
n/a
Abstract
THE OBJECTIVES OF THIS PROPOSAL ARE TO: (1) PRODUCE ALLOTYPIC MONOCLONAL ANTIBODIES THAT DISTINGUISH CLASS I ANDCLASS II ANTIGENS CODED BY THE RTI LOCI MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) IN THE LABORATORY RAT, AND (2) CHARACTERIZE THE ANTI-MHC MONOCLONAL ANTIBODIES BY BIOCHEMICAL AND GENETIC METHODS TO DETERMINE THEIR ANTIGENIC SPECIFICITY FOR CLASS I AND CLASS II ANTIGENS OF DIFFERENT MHC HAPLOTYPES USING 11 STRAINS OF INBRED RATS. THE ANTIBODIES WILL BE USED IN COMBINATION WITH OTHER PROCEDURES FOR GENETIC DEFINITION WITHIN THE MHC. PHASE I RESEARCH INCLUDED INDUCTION AND CHARACTERIZATION OF ALLOTYPIC MONOCLONAL ANTIBODIES AGAINST THE 10 KNOWN HAPLOTYPES OF THE RAT MHC. PHASE II WILL INCLUDE PRODUCTION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES AGAINST THE 10 KNOWN HAPLOTYPES OF THE RAT MHC.

* information listed above is at the time of submission.

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