CLUSTER ION PRIMARY BEAM SOURCE FOR LIQUID SIMS MASS SPECTROMETRY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$45,520.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19424
Agency Tracking Number:
19424
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3146 Manchester Court, Palo Alto, CA, 94303
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
William H Aberth
(415) 856-2412
Business Contact:
Research Institute:
n/a
Abstract
THE ANALYSIS OF EXTREMELY SMALL SAMPLES OF BIOLOGICAL COMPOUNDS REQUIRES EVER INCREASING SENSITIVITY OF MASS SPECTROMETRY. THIS IS EXPECIALLY THE CASE WITH HIGH MASS SAMPLES AND MS/MS ANALYSIS. THE GREATEST LOSS OF SENSITIVITY IN FAB AND LSMINS OCCURS DURING THE SPUTTERING CONVERSION OF SAMPLE MOLECULES IN THE LIQUID MATRIX TO SAMPLE IONS IN THE VAPOR STATE. FOR EXAMPLE, THE CONVERSION EFFICIENCY OF BOVINE INSULIN TO IONS IS ESTIMATED TO BE BETWEEN 1/300,000 AND 1/300,000. TO CONVERT A GREATER PERCENTAGE OF SAMPLE MOLECULES TO VAPOR, IONS RATHER, THAN VAPOR NEUTRALS REQUIRES A GREATER ENERGY DEPOSITION ON THE LIQUID MATRIX SURFACE. THE USE OF CLUSTER OONS INSTEAD OF THE CUSTOMARY CESIUM OR XENON ATOMS FOR THE PRIMARY BEAM, PROVIDES A MEANS OF INCREASING THE SURFACE ENERGY DEPOSITION AND THEREBY SAMPLE ION CONVERSION EFFICIENTY. A CLUSTER ION GUN BASED ON A LIQUID METAL ION SOURCE WHICH IS A CAPABLE OF PRODUCING CLUSTERS OF TIN WITH HIGH INTENSITY UP TO SM7(+) FOR LSIMS USE, WILL BE DEVELOPED. THE GUN WILL BE CAPABLE OF RETROFITTING TO MOST EXISTING MASS SPECTROMETERS WITH AN ESTIMATED IMPROVEMENT OF ONE TO TWO ORDERS OF MAGNITUDE IN SENSITIVITY OVER EXISTING FAB OR LSIMS GUNS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government