HER-2/neu T Helper/Memory Vaccine for Breast Cancer

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$224,700.00
Award Year:
2003
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA096169-01A1
Agency Tracking Number:
CA096169
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ANTIGEN EXPRESS, INC.
ANTIGEN EXPRESS, INC., 100 BARBER AVE, WORCESTER, MA, 01606
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ROBERT HUMPHREYS
(508) 852-8801
ANTIGENEXP@AOL.COM
Business Contact:
ROBERT HUMPHREYS
(508) 852-8801
ANTIGENEXP@AOL.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Antigen Express scientists have demonstrated that the li-Key segment of the li protein, acting at an allosteric site of Class II molecules, facilitates charging by suitable vaccine peptides at the antigenic peptide-binding site. The potency is enhanced (>250) times when the N-terminus of the antigenic peptide is linked to the li-Key peptide (li-key/antigenic epitope hybrid). Such hybrids composed of the Her-2/neu (777-789) epitope are much more potent in stimulating T lymphocytes of patients with metastatic breast carcinoma as measured by IFN-gamma release. In order to develop anti-Her-2/neu immunotherapies, we will: 1) design 9 li-Key/Her-2/neu hybrids using peptides predicted (or previously demonstrated experimentally) to act as good MHC class II epitopes and test their activity in vivo; 2) design and test in vivo a double hybrid composed of the most potent li-Key/Her-2/neu hybrid further linked to an experimentally proven CTL epitope; and 3) characterize the efficacy of our most potent double hybrid in a murine tumor model. We expect a robust augmentation of CTL activity to be obtained through enhanced Th memory/activity by li-Key. These studies address key questions to justify clinical trials with li-Key/HER-2neu antigenic epitope hybrids peptide vaccines in the treatment of breast cancer.

* information listed above is at the time of submission.

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