Maskless Lithography System for Generation of High Density DNA Microarrays

Award Information
Agency: Department of Defense
Branch: Army
Contract: DAMD17-01-C-0015
Agency Tracking Number: A002-2695
Amount: $119,943.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
6 Skyline Drive, Hawthorne, NY, 10532
DUNS: 796359289
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Marc Zemel
 Project Manager
 (914) 345-2442
Business Contact
 Kanti Jain
Title: President
Phone: (914) 345-2442
Research Institution
Recent developments in DNA microarray generation technology have made entirely new methods of gene analysis feasible. The DNA microarray can greatly facilitate research in the areas of drug and vaccine discovery, disease screening, and toxicology, amongothers. Therefore, the importance of a low-cost, high-resolution, high-throughput DNA microarray generation system cannot be understated. Current DNA microarray generation techniques suffer from severe limitations. The development of a new DNAmircoarray generation technique that has the high resolution of photolithography with the low cost of operation of mechanical deposition would significantly accelerate the pace of gene research. In this proposal, we present a method to generate DNAmicroarrays using a maskless lithography system. The maskless lithography system incorporates a large-array spatial light modulator to serve as a programmable mask. The spatial light modulator technology is integrated with Anvik's patented seamlessscanning technology to produce a breakthrough in lithography system development that allows rapid, high-density DNA microarray generation at low cost. In the Phase I program, we will optimize the design the lithography system and develop the processspecifically for DNA microarray generation. In a follow-on Phase II program, we will optimize the process and construct a fully functional DNA microarray generation system.The proposed system will enable the generation of DNA microarrays at higherdensities, higher throughputs and lower costs than possible with current manufacturing techniques. These advances will benefit numerous military and commercial researchers in the areas of drug and vaccine discovery, disease screening, toxicology, andbiological warfare agent detection.

* information listed above is at the time of submission.

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